Dr. Nikolai N. Modyanov is currently working as a Professor in the Department of Physiology and Pharmacology at The University of Toledo College of Medicine, United States. He obtained his Ph.D. from Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. For more than 30 years research in his lab was focused on the molecular aspects of ion transport across biological membranes, and primarily on the structure-function relationship of the ion-transporting ATPases that are receptors for cardiotonic drugs (Na,K-ATPase) and antiulcer drugs (H,K-ATPase). Together with colleagues they determined the complete primary structure of both subunits of Na,K-ATPase and discovered family of closely related human genes encoding different X,K-ATPases.One of these genes (ATP1AL1) was shown to encode a catalytic subunit of a hitherto unknown human nongastric H,K-ATPase, which is a new type of human receptor for cardiac glycosides.
Dr. Nikolai N. Modyanov is interested in the discovery of the unique BetaM proteins encoded by ATP1B4 genes, members of X,K-ATPase gene family.
