EDITORIAL BOARD MEMBERS
Candiolo Cancer Institute, FPO-IRCCS
Paolo Comoglio graduated in Medicine at the University of Torino in 1969. He then studied cancer immunology with Herman Eisen at the Washington University in Saint Louis and, in 1973, investigated the biological properties of the neoplastic cell membrane with Leonard Warren at the University of Pennsylvania in Philadelphia. Returning to Italy in 1974, he became Associate Professor and, in 1980, Full Professor of Histology at the University of Trieste Medical School. In 1983 he took on the position of Full Professor at the University of Torino Medical School. He has been director of the Division of Molecular Oncology at the Institute for Cancer Research and Treatment in Torino since 1996, and has been appointed Scientific Director of the Institute in January 2000.
Paolo Comoglio reached a significant milestone of his scientific activity when he developed new instruments for the study of oncogenes encoding tyrosine kinases (anti-phosphotyrosine antibodies and related technologies). By the end of 80’s, through these tools, he identified the Scatter Factor Receptors encoded by the oncogenes MET and RON. Later, his group discovered a family of related genes encoding Plexins, the transmembrane receptor for Semaphorins, and demonstrated that these molecules cooperate with Scatter Factor Receptors in the control of cancer progression and metastasis. His main areas of interest are presently focused on target cancer therapy by inhibitors or antibodies against the oncogene MET and elucidation of the genetic program underlying cancer cell invasion and metastasis.